MSCs stimulate angiogenesisAt 2 weeks after in vivo subcutaneous implantation with Matrigel, large macroscopic BVs grew into Matrigel plugs containing MSCs, while negative control plain Matrigel was avascular. We noticed the growth of small caliber, tortuous BVs in Matrigel plugs containing nike air max 1 dames coach 1000 ng/ml of bovine bFGF, and hemangioma like structures in Matrigel containing 50 ng/ml of murine VEGF 165 (Figure 2a Histological sections confirmed nike air max 2017 blauw groen the macroscopic observations (Figure 2m The MSC group contained more organized, branching BVs ranging from muscular arterioles to small capillaries. The mean vascular density (MVD) in Matrigel plugs containing 2.0 106 MSC/ml at 14 days was 415 BV/mm2, compared to 215, 112 and 0.50.7 BV/mm2 for the VEGF, bFGF, and nike magista onda ii fg negative control groups, respectively (PFigure 4).

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