In addition to the use of synovial biopsies for diagnostic purposes1 2 and pathogenetic studies,3 4 serial synovial biopsies have been used to evaluate the effects of novel treatments.5 6 This approach has been proposed to screen for therapeutic effects of novel antirheumatic interventions.7The increase in the development of a variety of new, targeted therapies clearly raises the need for sensitive biomarkers, which could be used for selection purposes during the development process. In RA a decrease in synovial macrophages has nike air max 90 mid winter gym red been shown to correlate with clinical improvement.8 10 No synovial changes were detectable with analysis of serial synovial samples from patients with RA who received either placebo or ineffective treatment.9 11 13 This suggests that analysis of serial biopsies could be used as a screening method to test new compounds requiring relatively small numbers of subjects. nike roshe run with skinny jeans The absence of changes in the ST after treatment would suggest that the therapy is probably not effective.To date, only a few studies have been conducted in PsA evaluating synovial changes after therapy.

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Samples are cut by diamond saw, and half is sent for assay and half secured for reference. Samples are sent to the nike air zoom terra kiger 3 weight ALS Laboratories in Zacatecas, Mexico for preparation and then on to ALS Global in Vancouver for gold and silver analyses by fire assay with an atomic absorption finish ("FA AA") on a 30 gram split, and for silver, copper, lead, zinc and trace elements by ICP analysis following digestion of 0.50 nike roshe run goedkoop maat 37 gram sample in aqua regia.The technical information herein has been reviewed and approved by J. Blackwell (P.

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